报告题目： Hepatitis C Virus NS5B “befriends” Host BH3-only Proapoptotic BIK Protein to Assist in Viral Replication

报告人： Dr. Jude Juventus Aweya, 新加坡国立大学

报告时间：2016年10月17日（周一）10:10-11:40

报告地点：科技楼报告厅201 

报告简介：

Cell-death modulation is an important survival determinant in virus-host interactions, hence most viruses encode proteins that interfere with cell-death signaling, skewing it to their advantage. For hepatitis C virus (HCV) infection, apoptosis and other forms of cell-death have been observed in vitro and in vivo but the detail understanding of this intricate viral-host interaction is still unclear. Using the HCV cell culture system (HCVcc system), gene profiling and siRNA-mediated knockdown methodology, we found that HCV up-regulates the expression of the host BH3-only proapoptotic protein BIK, and more importantly, that HCV NS5B protein interacts physically with BIK in the ER/HCV replication complex to assist in HCV replication. Some of this data will be presented.

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注：本次讲座纳入生物海洋学科继续教育课程。

 理学院

 2016年10月14日